• IVF Ostrava
  • Donor program +420 725 526 091
  • Orders +420 737 470 924

Ovulation Disorders

What you should know?

Ovulation Disorders

There are not many specific symptoms that would reliably indicate ovulation disorders. The usual suspect conditions include an irregular menstrual cycle, missing menstruation or pregnancy problems. After subsequent more thorough examination, other symptoms can sometimes be found, usually indicating endocrine (hormonal) disorders.

Symptoms of Ovulation Disorders:

• Amenorrhoea (missing menstruation)
• Irregular duration of menstrual cycle
• Obesity
• Significant weight loss
• Galactorrhea (spontaneous flow of milk from the breast)
• Hirsutism (abnormal body hairiness)
• Acne

Symptoms can show various combinations. Ovulation problems can include anovulation (missing ovulation), oligoovulation (infrequent ovulation) and luteal phase disorders (insufficient function of the corpus luteum, which forms after ovulation on the ovaries and produces an important hormone – progesterone). Ovulation disorders can be a result of many different causes, including general body diseases.

Causes of Ovulation Disorders:

General body diseases:
• Thyroid gland function disorders
• Hyperprolactinemia (abnormally high levels of prolactin)

Hypothalamus disorders:
• Tumors
• Impaired hormonal control and distribution as a result of:
» stress
» weight loss
» Cushing syndrome – congenital hyperplasia of the adrenal glands
» ovary or adrenal glands tumors

Hypophysis disorders::
• Tumors
• Impaired hormonal control and distribution as a result of:
» Polycystic ovary syndrome (PCOS)
» Weight loss
» Infection

Ovary disorders:
• Malfunctions:
» Genetically caused (e.g., Turner syndrome)
» Infectious
» After surgery
» Immunologic
• Polycystic ovary syndrome (PCOS)
• Tumors

The World Health Organization (WHO) Classification System of Anovulation Disorders | The classification system developed by the World Health Organization is used to determine the type of anovulation disorder. It is based on three parameters:
» Secreted prolactin level
» Gonadotropins (LH and FSH) level
» Estrogen level.

Group Diagnosis Description
Group I Hypothalamic – hypophyseal failure menstrual cycle does not exist, estrogen secretion not proven, prolactin levels not increased, low level of FSH (hypogonadotropic hypogonadism), no organic disorder in hypothalamo – hypophysis area can be found.
Group II Hypothalamic – hypophyseal dysfunction Many different menstrual cycle defects (luteal phase insufficiency, anovulating cycles, anovulating syndrome of polycystic ovaries, amenorrhoea), normal levels of prolactin and FSH, and detectable levels of estrogen.
Group III Ovary failure No menstruation, no signs of ovary functions, higher levels of FSH, prolactin level not increased.
Group IV Congenital or an acquired genital organ disorders No menstruation, no bleeding response to estrogen withdrawal after repeated estrogen treatments.
Group V Infertile women with hyperprolactinemia and manifest tumorous or inflammation – inducing processes in the hypothalamo – hypophyseal area Multiple menstrual cycle defects (luteal phase insufficiency, anovulating cycles, amenorrhoea) with higher prolactin levels and diagnosed organic disorder in the hypothalamo – hypophyseal area.
Group VI Infertile women with hyperprolactinemia without manifest tumorous or inflammation-inducing processes in hypothalamo – hypophyseal area Same as group V, but without diagnosed organic disorder.
Group VII Non-menstruating women without higher prolactine levels and without manifest tumorous or inflammation – inducing processes of the hypothalamus or the hypophysis Low estrogen production, low or normal levels of prolactin and FSH.

According to the WHO classification, about 97% of non-ovulating patients belong to group II and the remaining ones to group I. These two groups also represent patients who will most likely benefit from gonadotropine treatment to restore ovulation. Classification systems, like this one from the WHO, ensure that optimal treatment will be given to every patient. This system also allows a comparison of results from clinical and pharmaceutical intervention trials across clinical centers, and even across different countries around the world because it precisely defines (i.e., standardizes) the individual diagnostic groups. It is important to realize that although the classification systems provide useful guidelines for treatment, an individual treatment will be chosen by your doctor, taking into consideration your anamnesis, physical examination and laboratory test results.

 

 

Polycystic Ovary Syndrome (PCOS) Age Ovulation Disorders Endometriosis Tubal Factor

Kontaktujte nás

Pokud se snažíte otěhotnět dale jak rok (v případě, že je vám méně než 30 let) nebo déle než 6 měsíců (a jste starší 30 let), neváhejte nás kontaktovat a domluvit si konzultaci.

+420 737 470 924 | +420 597 689 180

Případně nám můžete zanechat zprávu přes kontaktní formulář, co nejdříve vás budeme kontaktovat.

Kontaktní formulář